D2-Lancaster Farming, Saturday, September 21,2002 Active Ingredients In Products WINSTON-SALEM, N.C. Pilot Therapeutics Holdings, Inc. (OTC Bulletin Board: PLTT.OB), a specialty pharma ceutical company developing and commercializing a portfolio of pharmaceutical and clinically validated over-the-counter pro ducts, announced that early re sults from North Carolina test plots of specialty plants that supply the active ingredients for the company’s medical food and botanical prescription products were extremely positive. Both borage and echium grew well in three test plots planted through out North Carolina. Borage is a plant that supplies gammalinolenic acid (GLA) for Pilot’s lead over-the-counter medical food product for the di etary management of asthma, Airozin (TM), which the com pany plans to launch later this year. Echium is a plant that sup plies a rare fatty acid for Pilot’s lead botanical prescription drug candidate for elevated triglycer ides associated with heart dis ease, stroke, and diabetes. The test plots were planted in the western, Piedmont, and east ern regions of North Carolina, and provide evidence that the specialty crops Pilot requires for its products can be grown throughout all regions of the Southeast. “The positive results from the North Carolina test plots of borage and echium are positive indications that Pilot should be able to increase efficiencies in its supply chain and reduce costs, which are critical factors to better position the company and its products for sustained growth and profitability,” said Floyd “Ski” Chilton, Ph.D., Pilot’s president and chief exec utive officer. “We are especially gratified that the ability to grow these specialty crops in the Southeast gives Pilot the poten tial to positively and dramatic ally impact agriculture in this region. Since our inception, it has been a primary objective of Pilot to combine biotechnology and agriculture to develop prod ucts that fundamentally im prove human health and NOTICE: FARM OWNERS Goodville Mutual Is One of the Top 5 Farm Insurance Companies in Pnnnsylv rnia WANT TO KNOW WHY? Liz Martin Martin Insurance Agency 459 C N George St Millersville, PA 17551 (717) 872-7756 Toll Free 1-877-791-5235 www marhninsurance com Affordable insurance for farm, home, vehicle and small business Agent tor Goodville Mutual Positive Results For disease.” Pilot’s chairman, Glenn Kline, who also serves as man aging partner of The Academy Funds, Pilot’s founding institu tional investor, also expressed enthusiasm. “The positive re sults from the test plots are an other accomplishment in a long list of milestones achieved by Pilot. The evidence of these achievements is Pilot’s ability to raise more than $lO million in equity financing in an incredibly challenging private equity envi ronment. With the added sup- Interferon With That? AMARILLO, Texas Some of the most significant medical advances in recent decades have come in the area of drug delivery systems the time-release cap sule, the oral contraceptive, the transdcrmal patch, the french fry...the french fry??! Well, maybe not quite yet but it could happen soon if an option agreement announced by Amarillo Biosciences, Inc. (OTC Bulletin Board: AMAR), bears liuit. The agreement signed bv AMAR with scientists, a re search institute, a biochemical company, and an agricultural cooperative in Japan will seek to exploit a recent discov ery involving the transgenic de- Inery of human interferon alpha through potato plants. Japanese researchers found that twd subtypes of human in teileion alpha could be ex piessed in transgenic potato plants (Journal of Interferon and Cytokine Research 21:595- 602, 2001). Now, Amarillo Bios cienccs will help evaluate the commercial possibilities of using such plants to grow potatoes containing human interferon alpha, which can then be fed to humans and animals, thereby ef ficiently delivering controlled doses of the drug. The potato leaves or tubers will have to be ted raw, because cooking will piobablv inactivate the inter- Would You Like port of Pilot’s important strategic partners, including Kings, Inc., Quintiles Transna tional Corp., John Hopkins and Wake Forest University Schools of Medicine, the company is now positioned to raise the funds to launch what we believe to be a revolutionary, over-the-counter product for the $7 billion asthma market.” The test crops were planted through the North Carolina State University Agricultural Extension Service under the di rection of Kings, Inc., a wholly feron '• This exciting invention fits into our efforts to develop low dose. orally administered inter feron alpha for man and animals,” said Dr. Joseph M. Cummins, president and CEO ot Amarillo Biosciences. “We aie eager to partner with inven tors Dr. Chihiro Suginfoto and Dr Takeshi Matsumura; Hay ashibara Biochemical Labora tories, Inc.; Hokkaido Green- Bio Institute; and Hokuren Federation of Agricultural operatives to commercialize technology.” Lancaster Farming Check out our Website www.lancasterfarmma.com owned subsidiary of Associated British Foods pic (FTSE: ABF), a U.K. company with $6.4 bil lion in annual revenues. Kings is a leader in the supply-chain management of high-value, spe cialty plant-derived products, where sustainability, assurety, continuity and traceability are key drivers for its customers. Earlier this year, Pilot signed a supplier and raw materials pro cessing agreement with Kings to provide Pilot with a turnkey ap proach to supply and process borage and echium for Pilot’s pipeline of OTC products and botanical drug candidates. North Carolina-based Pilot Therapeutics is a specialty phar maceutical company that is de veloping and commercializing a robust pipeline of pharmaceuti cal product candidates and clin ically validated over-the-counter (OTC) medical food products. A world leader in fatty acid metab olism, Pilot has pioneered Func tional Liponomics (TM), a proprietary, state-of-the-art re search platform combining fatty Co ibis La Dependable germination year in and year out. • 48” and 72” Widths • Knife spacing 2” or 3” • Full width seeding pattern or slit-seeding • Adjustable depth from 0” to 1 5” . • Cast notched roller for seed packing 4SSSmSSM!S • Gauge wheel or rear roller drive Deerfield Ag & Turf Center, Inc. RR 2 Box 212 Watsontown, PA 17777 570-538-3557 Detlan Equipment, Inc. 141 East Main St Silverdale, PA 18962 215-257-5177 Thomas L. 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The company’s common stock is traded on the Over-the-Counter Bulletin Board under the ticker symbol “PLTT.OB.” For more information about Pilot Therapeutics, visit www.pilott.com. Pilot Therapeutics Holdings, Inc. contact is Floyd H. “Ski” Chilton, Ph.D., president and chief executive officer, (336) 725-2222. Pennsylvania Hines Equipment Stoltzfus Farm RT 220, Belwood, PA S6fviC6 814-742-8171 Cochranville, PA 610-593-2407 Keller Brothers R 7 Box 405 Lebanon, PA 17042 717-949-6501 and 1950 Fruitville Pike Lancaster, PA 17601 717-569-2500 Pikeville Warren County Equipment Inc. Service Center RD 2, Oysterdale Road 228 Route 94, Oley, PA 19547 610-927-6277 Me www iandpnde com Stouffer Bros Inc. 1066 Lincoln Way West Chambersburg, PA 17201 717-263-8424 Valley Ag Turf 817 Tobias Road Halifax, PA 17032 717-362-3132 Rodio Tractor Sales North White Horse Pike Hammonton, N J 08037 609-561-0141 Blairtown, N J 908-362-6916
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