t - .1. 4 . 7. 7 1't ~..., ,. ::t,t-,:'-'- - :':."1 -. , = ,- - - „. :•J,. ,-, , ,- ' '.:;- , -- T. ‘--"'-'-‘. [ .?.' 4'• .4.:,',; - ; , -.2!, _F,:',-- -- .;_ . - : ,', ' .--. , !-:..,t , -; :I t l.p z 1 n::,:' , ....,: --,•.:.-:„.,", - 'l . .',.:'',-, 4 -:.1: . --.:.: - 4; - - Al , ' • - . -5 ,4 :, ............. i..:2 410 biaivii_gig jtlai . "Pli'ar Al titie'-Gola an -Heitri - agi ye:sari it Ahead I • . NEW GOODS" NEW GOODS?' • Grealdd Bargainis than ever,can•nowleinid a, thesigtioftV•Ntio Gaiden,Ba-14- . !• , e,onlidatirot ' , betwaen Thlrtland.Foarth;-wherb is atlel *pen - P.l' l a spladdld•Mock Jo f whiter - Dry•Loods, cheaper. than the • samo quality of . Goods have ever been offered ,ies:Pitia 51.'L. RUSSELL, No. 62 Market street,:bevamen. Thiid — ifsid - .Fisattkr. s treens, sign - of the - .Big Golden - Bee, Hive, has now receircli t ima offem to,biximmerout: ens - - tamers and. the U lntgest„clipapest and 'most epleMlldattick,o f - Wlntei'Dty . Goads' ever'infer;• ed - in e this cztyr,..;,The,se.Gtailstitva;lieen•pincliasediatlia Eastern. Gitiesisitiee.the late Sill an'arices, and will Ls . sold to - cash buyers at a great - reduction, much Cheapei 'than they could have been sold in the early part of the . Atnong this large lildfcifenaivei found astanly - eftpice and fashionable Hoods of the incest im t LADIES! DRESS GOODS: ' • • SoirleXCiabinerea, all wool, aheautial attiele 3hariy 'eat'd do. do. . figured and plain Silks and SatiusAititin, striped sad • Sturrlerde Lanes all wool, very cheap; • Mazarine Blue DC Lames, low prices ; • Frinfeh Merinos, all colors, extremely low. - A!largansiortine tit o(.4o6lM:tames De Laines,new est tasigns, from 121 t 0.% ocuts.pe r yard ; theseare - very. cheap. Also, a large-stook of. Alpacas from 121.t0 'cents per yard, all Colors. Ualie,golll.:bilirgain j with u splendid - assortment of bonnet, ribbons of the latest Mi. - podation. , Also,..,velvet.ribbOns all :widths and colors. very cheap, a beantifulassortment plumes and artificial. Bowers; bonnet mains mtd-vClvets, all colors; French worked ames.and Mallets t...searfs, cravats, gloves and ' hosery, all at redace*ptices: • ' SHAWLS! SHAWLS!! Best assortment intheeity, arid very cheap Long and . _ . Sqltarts:Sintvils,licalquitEty. Tarkerie and Catibuiene Shawls 4 • pluck and colored Cloth, t 10,..;•. , . • .• Plaid ttlanketShasils,till qualities antiprices. • • , BLANIMTS BLANKETS Oa large_A mock of .Ihanketis, , all qualities, w.hieh,vrill be sold theapet than c.sitt be found elsewhere.. - ,• . • •••. . DOMESTIC.GOODS, , • .•G HEAEER THAN. THE CHEAPEST! - Alarge stock of Calico., Goad dark Calico. fast color's, only 2.cents tier yard; best quality Britishand American Printe,Mili DI cents pevyard, yard wide. British Purple Priats, HI to : Mk;•alarge supply red, white and_ r yallow •Elalutelaeorrie as low as 101 cents per yard, vertx,,,heat;•• Bed 'licking, from 8 total cents , per yard. Also,h /nue .stoca_af,Checks,Shirting Stripes, Cassino's, Ketiatieshi'' ' leans and Liiiseys ' together with a very exteitsiii , *.sla; sorlment of Lileuened and unbleached Muslin!, frordlSO eantstaiyard, cheatiest yet; good yard aide unbleach .- ed:Pduslimr, - only 5 cents per yawl; blenehed from alo Esehrtts pet yard: - All of which will be sold off -. at iedhced Prices, at the sign of the' New Golden Bee Hive;isi Market street between Third and Fourth stn. ; No, c2 : •••-••• (deellattfs • • Whl. L. RUSSEL. • , Business Card• • TntithrTgAb WELL ASMONOPOLIES )111IST PALL: ' sT. P CES; fIICH fas.i.rrill be proVeli by ballilig . at !deal:lsms:B Fashionable Tai fon lig Eitabl ishmen t, TO ril street, St. arles Banding, . • . Morro: .Setzu..proj . its and v:ARIES4 : Frilat and good. COnestrnon: Wry jar in the hackground... My old customere,and all,otheta, are.respeculilly rmed that lam waiting for them. McGUIRE, 't . E WOULD ftIitPECTAILIN invire-the attention - Of our friends and the pablic to the great variety of WINTER COA.TINGS And other articles ;we have just'receigerl—amougst which will he found 0:c.0 .- realest variety of BLUE, BLACK, DRAD,Its.d Pk:MIL Ic olored BLANKET,. MACKINAC, and BIEAVER CLOTHS.— FRENCH rout ENGLISH CLOTHS, .CASSLIIERSS, VESTINGS, 4-c. The above Goode having been bought for 'cash, at extremely tow prices; we are prepared to ne cornrnottate all who may - Maur us with their patronage, with good Clothes, at lore prices. Give us a cull. frf Remember, dlB Liberty street opposite foot Of 7th. nov3o, ItIeMULLE ' N it DOWNING. i Clothing I Clothingl I Clniiiing I lab, -- The Three Sig . POOTS VS. The Ireetern World .72 150 *OOO `ELL SELECTED GA RATEsTs now . , , , made and ready to tie offered on the most liberal terms to my old customers and the public in general: The Proprietor of this far-fained and extensive establishment has now,after returning from the Eastern citiek, at roach trouble arid expense, Just Collll4lleltd his fall anclarinter arrarn mettle to supply. his thousands of ensterne r rs With one of the most desiruble stocks of Cle aning that has ever been offeredin this or any other mar ket west Of the Mountains. For neatness"in stYlc and workmanship,. combined 'with the very lowprice which ther,Will:he sold tof,.must certainly' render the old unri valled ThYee".airr'Daois one:Of the greatest tittmktions of , - me western con - atty. It is giatifying tome to be able to ' announce" to•any,numerousfriertda at , home ands abroad, that hotwithstadding the extraordinary- efforts 'width 1 ' have made to meet the many calls in my tine, it ix with diffiebilty I can keep time With the constant rush drat is made on this, establishment It is a well established fact, 'hat my:Sales are eight or ten times larger than any othec house in the trade, and this .being' the ease on the - amotint sold, I can affrod to sell at mach less profit than ' othe - coald' possibly think of doing if they wished to covcontingent expenses. ;I intend to make a 'Clean sweepof ell.mypresentstockibefore th e beonnjug-of pert year; corning'to thisconclusion, I will make it -the inter- est Or everyman. who Wanis.a cheap wintersult, to call and Parehimer at the Three Big Doors. - . - -.. , , . optil-ftve , , -'. - - - - - Jour4 Nretc.) , ,AKEr. XriztvWititiKlCT.iv doi:rs..-ite . Aived di the Ire. 11 City Clothing Store. a filletutjttutportment of Cloths, consuming of fine French, Thiglisliand Ameritan ,Pinto, black and limey Cassienere,, of the most modern Styles; fine *aril Cashmere Vestitig a , Silk Velvet, Plain Mid Fancy Satins "'itill Of . which we Will make up ar them - din reasoptiblelirices,' in a - durable-and fashicsnable stfle. Reidy madeClothine, of all descriptions; Lady's (Hoak* ' of the 'mbilf - fahimialite patterns.' Neck rind Pocket Ildkfi.,'Suspenders, Bosmns, Shirt Collars,' and everyiartiele usually kept in n Clothing Stare. Country ,hterchruns,'bYforc purchasing elsewhere, 'will find it to" their advantage to call at the Iron City Clothing .Store, No. IMLlb . erty street, immediately oppositi ‘ - the '.iiniiith of Market. , - ' tocUB4ll- . • ' C. NrcLuslcrx. . . . • Jaboos, W. Wo,odwell, . , ... ... . . MODER.N-A,.ND .ANTIQUE-FURNITURE , ,' -No 93 Toren STREFI, PITTEBERGE. • ' SIA LARGE and - splendid nnEorlMent of Furniture. suitable tor Steamboats, Hotels, and Private Dwell: idgtheonstainly oil band, and made to or ler. he present Snick - on hand cannot be exceeded by nify manufactory in the Western country Persons wishing to purehase, would do well to give me a cull, as 1 am de-, terminedMyprices shaltpltaSe. Part of the con - ems iii-- Tilie a Tete; • Buffet Etagele ; LGIIIII XIV. Chairs; 'Queen Mirabelli Chairs; Tea Poyse 1 Fruit Tables ; Toilet-Tables; Louis XV. Commode r. French Mahogany Bedsteads; Piano Stools ;' 50 Sofas, with plush and hair cloth covers ; • 5011.thegany Rocking Chairs; 40 foren Parlor de,. 30: . t Fancy . :• ,' . do. - 25 Centre Tables; . I . 20 Pair Divans ;4 pair Piet' Tables ; 15 marble lop Dressing }tartans ; 8-Wardrobes; 8 Secretziries and Book Cases ; 20 marble top Wash Stands; . 4 Pair Ottomans;' 8 pairFaney Work Stands. A !ley large assortment of common Chairs and Other Furniture, too nomerois to mention. Tr. Steam Boats furnished on the shortest notice. and On the.Knost reasonable terms. Celia , ~. z. ; . City Livery Stables. ..a fe ! Tag subscribers having purchased from Charles Coleman the nbove.Stables, and in . tending to increase their stock of llorscs. Carriages, Buggies. &c., would respectfully solicit rr. share of patronage from the public. Horses kept by; the .day, week. month or year, end additional stalls ate boinp.erocted, in the-second story, tar the ac commodation of .Canal stock. febt.ilrn ' r ROGEILS. te OBEY. IN retiring from the Livery` business, I with pleasure (from 11 fog acquatutance) recommend my successors to the patronage of my friends Q-nd the public. , feb23tjw -CHARLES COLEMAN. nitow te c e Carr [nips Mancsfitc.tory,,, -Diamond 6ettreen Wood and Smithfield streets E. M. BIGEI.9Ik wonld .respectiutly it- inform the publie n that at his Factory c• _„--..0•77 at all times lie foetid a 'urge supply of Family Carriages... Harouches, Buggies, and all kinds of Fancy Carriages, Nual in elogance.and neatness to auy found in the East. :_Contracts for any numner of Carriages. Buggies .tutil 'Wagons, .will promptlyifilled. All work of his own manufacture will be warranted. - RETratitcks—Col. R. Patterson, R. H. Patterson, E. D. Gazzum, Robert Robb, Esq., C. L. Magee. and Alderman Steel.• ifcbili;ll.3m MR. DUFF'S - - BOOK-KEEPING AND warniv.; ROOM, . NORTn-wkra. CORS1:11 OF SILOIKET ST- AND TILE DIAXONI). WORTreEIGHT PUPILS are now iii attendance, lotd Mr. D. has engaged in the same building, and Will have in rehdincsa rrr a few weeks, a private apartment for Ladie4as well us more extensive accommodations for Gentlemen. His new Treatise upon Book-keeping is becoming the standard book . in the Eastern Cities_ It i. nniversall)t admitted by practical merchants to he the first.complete work on the subject published.- •Ilnurs 10 to 12, 2 to 4, and:7 - to 10. Professidnal assietance given in any ease-of difficulty in partnershi't -settlements oropenin books. tMetft :Wholesale: and Reinll4 l , .9ADDLE;IiARNESS AND TRUNK hl'A NU FACTO R OBBRTIIARTIAIIt, begs Jeave to, in- .LIL, form his friends and the public generally,. - that he continues to occupy that large and corn, : WO 'modiousStdre Room,, in formcrly occupied by.Sauel Faint. esti:wk . & Co, No. corner of Diamond alley and Wood street, where he keeps a large and general aseoruneul-of Saddles, 'Thistles, Harneii, Trunks,"Carpet Bags, Saddle Bags ; Valisti;Bnffalo Robes, 'Whips, and all miter arti des in his line. . He also ktept 'constantly on hand, and is prepared tc, furnish to order, all kinds of Riveted Hose.tn nnufactu red of the best realerial, end jail stylt.: of workannohip equal 20 the easteht manufactured , pm ele, and at 66 per cent- Countryitterefuints. and Farmrra. would do Well to call and examint hie stook before norchasing elsewhere. as he Is determined to aell .firot, rate articles at very low [Er Don't? forget the place, No. - B'6, cornet of Wood treet and Diamond Alley. • - - . ap26 XTEW DAEUERREOTYPE ROOMS, Burke's Su ild jr ings,.Fourth strett—HorG Oc: AN - nfo:rr, Deguerreo. typists from the Eastern cities. would call the attention of ,the inhabitants of , Pittaburgh, and the neighboring tovros, 23 their Daguerreotype of citizens and others, at rooms in - I. the third story of Burke , s building.3th at. Persons wishing pictures taken may rest assured. that no pains shall be spared to produce- them ia the "highest perfection el the art. Our instruments are of the'most pow erful kind, enabling us to exectita pictures udsurpassed folicitedor high finicall aleanand e dlfulnes ine.t to nature. The publioare - s to ru x th am " , = . Persons sitting, forptctUres are neither teßuirred 'or ex. . pected to takethem 'unless perfect satisatclion N. B. Operators will find this a good depot for stock and chemicals 117 - Instructions given in Liman, totkeliting :the more cent Improvements. ~'• - 'jan7 4 k • z .-‘Y, ‘ ll s .7 . , - 4. ; ,,, - .;,;; MEN Paisage tor from ffii o und o Iceland, SCOTLAIs7 I 42M.NVA TL'mmts nocrike mtvior ••:, • .r 4,4 q•Shi:Plotc•Za ci ; • ' • • • 75p • dv-cp#4 • 63 , South:itrrit,'Neio 'York,' gad 3)3; Waterloo Road' , Pt:lino:vs sending to the Old Country for their friends, can have thenkblotigitt `out by tbe Regular Line. cif Paek ets,sailing from Liverpool ou 16th.3iit or Nth of every month, coMprising-thei` following Ships : „Pidelia, • .Siddons, • • Heiiry Clan' Afottinguerr • Colombia. • - • Constellation, Roaciani • Patrick Henry, , Chnibridge, Isaac Wright.- • Waterloo, COlMitUtioll, • Ashburton, - New-York, • • Garrick. West. Point, Queen ot the West, Montezuma; Vorkshire, ' Sheridtuf, • ••. -New !World,' :Liverpool, • Oxford. . • - - John R.'Skiddy. Or in the first clans American Ships ; sailing from Liv er'pool and the Irish Ports every daY,!comprishig the— St. Patrick,. St. George, Andrew Foster, Yorktown, Creole, ' - Memnon, Probes, Elsinore, ' Wm. A. Cooper. And many others, which this limited spice will not ad mit of hero " numerating. • • P. 1V.,131 - RNES & CO. are the sole-Passengar Agents for the Steamship SARAH- SANDS, Bei:appointed sail ing dam- far 1849, are as follows; ' , Prone Liverpool on 90th. Lanuary,.l.S,,th March, 4th June, 6th August and Sib - Oetotierri.froni New-York on kith February, 3d May; sth fulf.September, and 15th November. Philefore; those wishing their-relatives out early in the Spring, will ftud,it to - thairinterestio patronize this Old'Extablished House, our arrangements being so per fint,that no delay or .disappointment• can occur. vDrafts.rti sight for any amounton the-. National Bank of Jreland, its btanelies, ,ke.,A.e., at all times for sale. Ap ply to, or , address , by.derter, post-paid, . „ P. W. BV,RNES & CO, 63 South at., N. 'Y., .• . -and 36 Waterloo Road, Liverpool. JOHN THOMPSON, 156 Liberty Street, Pittsburgh. Otto tf I.INE • itair: • rang Eta) PITTSBURGH TO ER3,E: RE - SHIPPING.—The Bouts belonging to this Line 111 • have been piir in fine order, and axe mow running, regularly between Pittsburgh, and. Erie. touching at all intermediate Pbrts along the Climatic ARCM* will always be at the wharf, under the Monongahela 'Bridge, and one will start regularly every other day. The Peopiel Transportation Liue has every facility for carrying .Freight and Passengers. The boats will be towed to, Beaver by 'steamers; and will proceed to Erie with great dispatch; by the etunds. The, boats are commanded by experienced and careful men—ull of whom have an in terest to the Line. • Ey' Goods sent by the Line to. Erie maybe forwarded to any point on the Lakes. For Avight or passage apply to 1- L•KIRKPAITRICK, • . • - Agent. Water street, Pittsburgh. : CLARK & ve Bear.AGENTS , R. W.-Certarnotram, New Castle. TROUTMAN. & Scitscrr Watute.s & Co., Middlesex. NIJLTON LIVLL, s.lle/11)11. • JosagsllCCLtrrs. ...Sharpsliurgh. W . & Lowkr, Clarksville Nino & McFanikan. Big Bend. S. C.-Ptenrata, West Greenville. linraintcs, Adatneville. •. W. 11. Idanitav, W. Wanswoirru & Co., Sherman's Corners. %'M. Pri‘v-en. Conveautville. Sp ring Corner. W. C \VARNER, W. TILER. Lockport. E. Fisn, Girard. A. Klan, and B. TO3TLINF.AI4I &CO., Erie. The following Agents in Erie will receive and for ward Freight to any Port on the Lakes, shipped by thiii Line: Galln.her, John !learn, G. Baverstick & Co., Jadati Kellogg. Kelsrie & Loomis, Walker & ( r ook, Jen Pittsburgh Pisrtable Boat Line. .. 15 48. Foi the Transportation of Freighl to and from PITTS P LIRG 4. I.IIII ..ADEI. I 'IIIA,IIALTLMORE,NEW YORK, IIO STON,,ke. BORBIDGE 4- CASH. Philadelphia. TAAFFE ¢ O'CONNOI4, PittrbartA. firtlllS old eatablisbed LinUheing now in full operation. the proprietors have made extensive arrangements to torwarel Gonda and Produce wadi despatch, and on the most favorable term. They confidently hope, their well known promptness in delivering goods—peculiar safety in mode of carrying—capacious warehouse. at each port. affording accommodations to shipper. and camera of produce,—together with their long experience and hares minutg nalvntion to itusineas, willaecure to. them a con tinuance of that biteral patronage they hereby gratefully 'ackticeviedge. , • ~ .A.ll consignments by nal r this line receive chargeit paid. and forwarded in a any fo required d, free of charge for cominissiou, ad enticing or storage. No interest, dirt-city or indirectly, in atettrabonts. All eoratattnicrisout promptly 'attended to outtpplieu. tion to the following agents: . BORI3I.DGE CASH, 27 - e. hiarket etreet,Philadelplua. ..YAAFFE &.-OVONNOR, l'ikhorgh. (J'CONNURS & CO, • North street. Balihnore. W/LLIANI WILSON, • eti, Cetiar.rtreet.New York. Merchants irraniiportation Line. VIA .CANALS AND HAILHOADS,FOIt PHILADI.IL ;: PHIA AND KAI.TIMOHP... GOODSconsigned tut. tare will he fOrmarded out delay,. and att •e lowest eurrentrates. C. A. ItI'ANUI.TV & CO., Canal tasin. Penn street. Pittsburgh. & REYNOIsDS, 2.12 and 31 . Market street. Philadelphia. HASH ; & C0.,- Smith's wharf, Baltimore. /11erc,hantf. ...Way Freight !, Line. .: 1848 . atia=l t o transporintiunof way freight duysburgh, Water street. and Pete ralittruh. This Line wit, formed for the special accommodation of the tray busious. The proprietors, thankful (or the very liUeral patrontip,thoy have received duringthe last two years, respect f ully inform their old eustoiners and the public generally, that they are now better prepared to deliver goods at any point on the Canals or Railroads with promptness and despatch. PROPRIETORS. JAS. A. LORE. GEORGE TRINDLE, JOHN AIILBER & A otxrs— C. A. APANchrg k Co., Pittsburgh; Jozni MILLaa, Hollidaysburg; • PICKWORTII te Warns. Johnstown. Restart:govt....Smith &Sinclair: J. &J. ItPDevitt;-0. & J. H. Shoenherger; R. Robison & Co.: R. Alonre ; Bagnley & Smithv.tohn Parkeklym. Leh mer & Co.; 0. P. Stroettber geri Pitklturgh. , Inereheinta , Teaueportectien Line, . . F°4 'the. Transportation of Merehandize and Produce 'to Philadelplna' and Baltimore. Goods consigned to our care will'Le forwarded without delay, at the lowestrates. Bilk of - Lading transmitted, and all instructions Promptly attended to, free from any extra charge for stor age or commission. C. A. I'iI'ANUL.TV & Co., Proprietors, Canal Basin, Liberty, st.,.Pittsbargh (Gazette.only, copy.) READE ATTORNEY AT LA tV. TD.Partnership heretofore existing between JOHN I D. MAII0l's; and READEAVASHINGTON, has been dissolved bysnutual consent. Thu subscriber may be found at his office. on Fourth street,lsctween Senishlichl nod Grant ste , Pittsburgh. at all times when not engaged in Court. ILEADE WASHINGTON. Saloon and Restaurant, N 0.115, 63, and 61 Wood street —' 4 ,,"Phe subscriber would respectfully inform •-. y his' friends and the public generally, that he has had the above: well known establish .. ment lined up to a very superior style, and is now pre pared pith every rec/uisitc, to serve up all the dell Ca. eiot, the Bi•af‘ori . 4ttorcls, OYSTERS, stevceil,Ried, roasted, or in the shell; to gether with hot entree, tea, chocolate, beef steaks, mut' lon clams, venison ausl game, at short notice, and at all seasonable: hours, in a Style that Cllllllot be surpassed is Pittsburgh, XX ALE of the best brands. Importa Segars in eve ry variety. He Would also beg leave to state, that is,prepared to furniih DINNER PARTIES of any number, in a au peOor manner; SUPPERS for Balls,Socie ties or private Parties. 1I PItIVA.Tif ROAM;Wilys in readiness. Nclavapers will be kepL Oli file frunt,all +miners. deck.' JOHN DONNLLEY. • A Card. -MO THE ENTERPII.ISING.—A. rare chance is now 1.. presented for the safe investment in a business.en -tirefy new; one adapted to the man of limited. its well an to the man of extensive resources; yielding a profit - from 'capital and enterprise beyond any operation of the day.: 11 is the complete, monopoly of a staple artiole,nb.; solutelnneeessury and essential to evert tutnity,•ns well as indispensable to the meelmitic, artizan and profes sional than To capitalists, an opportunity offers-itself for a lucrative employment of either large or small sums, tiringinev immediate and highly satisfactory returns.— Those desirous of embarking in a pleasant, genteel busi ness, ore invited, with others, to call at the office of the undersigned, examine the article, and form their own ittelpficitt, from the facts presented. (Ane.—Exchange Buildings, St. Clair street, ilextdoor o Esquire Jo hn s' office. Oyster, -Agency, • . . OYSTERS CHEAPER THAN THE CHEAPEST._. Received this day, direct from Baltimore, by Ex :-peens, Fine Fresh Oysters, which I will sell low, at my AjOre,;u the Diamond ; also at liVrn.Rrarnera„ corner of Second and. Smithfield streets, and H. C. KellVej corner at Fifib and Market alley. will receive them daily .at the atiiive•places. All Oyef.ess warranted; money r e t urne d , I at good:. ' nov4s ; F. R. DRAVO _ . IFIANGEADLP. SIL I C.VISITS, Fog , Cultiermas Pans - Wri.. 11:. - 71V-,fifitrpfik ban on haul a few very . handf come hangeable IV:nits, very sufiable for Chr istmas presents, which belt; selling at reduced prices. Also, handsome Drese, Saks, Sean, superfine new style linen carebrinAlkits,,, dec23 Western Piety York College of Health. 207 MAIN STREET, BUFFALO, N. Y. DR. G. C VAUGHN'S VEGETABLE LITHONTRIP TIC MIXTURE. celebrated remedy is constac y increasing its 1. fame by the making all over the world. It has now become the only medicine for family use, and is particu larly reefimmended for Dropsy : nil stages•of this corn' plaint immediately relieved, 110 matter of how long stand ing. (See pamphlet for testimony.) Gravel, and all diseases of the urinary organs; for these distressing complaints it stands alone; too other ar ticle can relieve you; and the cures testified-to will con vince the roost skeptical ;—(see pamphlet.) Liver Com plaint, Bilious Diseases. Fever and Ague. To the West especially, and wherever these complaints prevail, this medicine is offered. ND mineral agent, no deleterious compound is a part of this mixture; it cares these diseas es with certainty and celerity, and does net leave the sys tem torpid. (See pamphlet.) Piles, a complaint of,, most painful character, is immediately relieved, and tt cure fol. tows by a few days use of this article. It is far beyond any other preparation for this disease, or for any other disease originating ILQUI impure blood. (Sec pamphlet.) Debility et the System, Weak Back, Weakness of the Kidneys, he., or Inliumation of the same, is immediately relieved by a few days use of this medicine, and a cure is always the result of its use, It stands as a certain reme dy for such complaints, and also for derangements of the female frame, Irregularities, Suppressions, painful men struntions. No article has ever been offered, except this, which. would touch this kind of derangements, litrivy be relied upon as D sure- and effective remedy; and, did we feel permitted to do so,. could . give a thousand names as S roof f cures in ths distressing cus of eon - m/7. Ode pa o mphlet. All i broken down, l d s ebilitated cons tu dons, frotn the effect of mercury will find the bracing (rower of this article to net immediately, and the poison ous mineral eradicated from the system. Eruptive Diseases will find the alterative properties of this article PURIFTTIIEBLOOD,aI I d drive such diseases from the system. See paniph!et for testimony of cures in all diseases, which the limits of au advertisement will not permit to lie named here' Agents give them away ; they contain 32 pages of certificates of high character; and a stronger array of proof of the virtues of a medicine, nevi er appeared. It is oils of the peculiar features of this ar ticle, dint it never fails to benefit in any case, and if bone and muscle are left to - build upon, let the emaciated and lingering invalid nova ox, and keep taking the medicine as Jong as there is an improvement. The proprietor would creation the public against a number of articles which' come out under the heads of SsasseAutu,ss, SYRUPS, Ae., as cures for Dropsy, Gravel, Sr. They are good for noth ing, and concocted to gull the unwary: zoccit TOFU NOT. Their inventors never thought of curing such diseases till this article had done it. A particular study of the pamph lets is earnestlyipolicited. Agents, ti and all who sell the ar ele,ure glad to circulate gratuitously. Put up in :10 oz. bottles, at 52; 12 oz. do. at $1 each—the larger holdin g a oz. more than the two small bottles. Look out and not get imposed upon. Every bottle has " Vaughn's Vegeta ble Lithontriptic Mixture," blown upon the glass, the written signature of "G. C. Vaughn" on the' directions, and "G. C. Vaughn, Buffalo,"stapped on the cork. None other are genuine.. • Prepared by Dr. G. C. Vaughn, and sold at the Princi pal Office, 207 Main street,'Buffltlo; Wholesale and retail. No attention given to letters Unless post-paidorder from trwolarly.ewiliorited Agents axerrd. Post-paid let ters, or verbal eommunicatious soliciting ad vice,prompt -ly attended to grunt. r . Offices devoted exclusively to the sale of this article— LW Nassau at., N. Y.; 292 Essex at., Salem, Mass,; and •by the principal Druggists throughout' he United States and Canada ; as Ageius. HAYS & BROCKWAY Agents, No. 2, L4berry Isl., near Canal Basin.. COLVFNI Ac MYERS optusorelak--PIASI.. • , E. W. 141ses.M..,i' co.,Vim - am; & . 0 01 94 Wall PI ), Liverpoel, Englatia; t • ../Linsileeltfebtv inform their, friends thepublic,have Gene. • tal , Shipping and' ComnusSurh Business, t 0.., .., , , . , 4/ /together-with the' General PosseagerPustness, ftna, tiedcertificates - of passage from Lomlon, • , 1 41.verpoot Dublin, Belfast, or any part of Ohl Country to New York, Boston und • Philadelphia, on the melt: reasonable terms. Drafts and Bina of tichangi, from ..£1 to any amount on the'Royal:Bink.of Ireland and its. branches, and on Liverpool. The-days of sailing of the Regular Line of Liverpool Packets, its-fixed upon:are time 21st and fflth'of every month. - ,These Shipsnre all of the largest class, and aro eotn -inandcd by men of character and g„aperience. The Cabin • accommodations am all that an be desired in point of splendor and convenience. They are furnished with every description of stores of the best kind. Punc tuality in the days of tailing will he strictly adhered to. Packet Ships Roseins, Siddons, Sheridan and Garrick, are vessels of the largest class; and those desirous to bring out their friends, cannot select finer or safer Ships. Passage can be secured at the lowest rates. New tYrleans Line of Packomsnikweekly.. For p age or freight, apply as above, or to ass- JOSEPH SNOWDEN, o EDMUND SNOWDEN, r dee It] Corner 4th and Sinithar Id sts., Pittsburg . Hamden & Co.'s ty "- 4 . . I 0; NEW PASSENGER • . i , , Alt 11.' A NGM Di RAY' T S-..' 1 . 'Er :Hereafter, alt Steerage Passengerireoming Roln - Rutdpe, engaged in America to come over, in either of thesauri/I of HARNDEN & CO., wilt be furnished with the following Provisions, or their eqnivalettLin other articles equally good.—See Act of Congress, Nay 1:, 1845. .T IH" 'LAN will prevent stekness'on board. Hereto fore, when Passengers found themselves in Provis ions, many of them came on uo‘rd entirely destitute, which often caused much sielinesa and death. 35 tbs. Bread, All of good qualb 10 " Rice, ty, and one-tenth 10 " Oatmeal, - of the Provisions 10 ". Flour, furnished ,will he 10 " Beans and Peas, delivered to each 35 -"--Potatoes, Passenger every I pint of Vinc W ent, week, with a out. .. - 60 gallons of Water, I ficient supply of 11.1 Ihs.,Salted Pork, free from bone.) Fuei for cooking. Each Ship in this Line will be properly ventilated, and a good house over the passage-way leading to the Pas sengers' apartment. The Cumboose and Cooking-ranges. for the use-of Passengers, are kept under cover. livery attention will be paid to promote their health and comfort. Agent at Pittsburgh, JOSHUA ROBINSON, le 7 Fifth st., near Wood. Tips . cotes Geneisi.4mtgratiloilOitioe. wth REMITTANCES and Passage to and l a from Great Britain andlreland, by W. & J. T. Tapseott, 75 South st., corner of Maideu Lane, N. Y., and 96 Water loo AMA, Liverpool. The subscribers, having accepted the Agency of the above House, are now prepared to make arrangements on the most liberal terms with those desirous of paying the passage of their friends from the Old Country; and they flatter themselves their eharaeter and long standing in business will give ample assurance that all their ar rangements will be carried out faithfully. Messrs. W. & J. T. Tapseoti are long and favorably known for the superior class, accontmod anon, and sailing qualities of their Packet Ship. The QUEEN OF 'PH E WEST. SHERIDAN, GARRICK, tiorrimwrie. ROSCIBS, LIVERPOOL, and SI DDONS, two of which leave each port monthly—from New York the 21st and 96th, and from Liverpool the 6th and 11th; in addition to which they have arrangements with the St. George and Union Lines of Liverpool Packets. to Insure a departure from Liverpool every fivesdays. being thus determined that their facilities shall keep pace with their increasing Patronage' while Mr. W. 'I apseett's constant personal' supenntendance of the business in Liverpool is an midi nasal security that the comfort and neeornmnitation of the passengers will be particularly attended to. The subscribers being, as usual. extensively engaged in the Transportation Business between Pittsburgh and the Atlantic Cities, are thereby enabled to take eharge of anti forward passengers immediately on their landing, without a chance of disappointment or delay; and use, therefore, prepared to contract for passage front airy scn port in Great Britain or Ireland to this city, the nature of the business they arc engaged in giving theta facilities for carrying passengers su tar inland not otherwise atj tainalrle; and will, if necessary, forward passengers fur- Kier West by the best mode of conveyance. without any additional charges for their trouble. Where persons sent for decline coming out, the amount paid for passage will be refunded in full. REMTITANCES. The subscribers are also prepared to give drafts at sight for any amount, payable at the principal cities anti towns in England, Ireland. Scotland and Wales: thus of a safe and expeditious mode of retaining tends to those counters, wlnah persons requiring such facili ties will find it to their Interest to avail themselves of. Application Why post-paid) will be promptly at tended to. . TAAFEE A °TON NOR, Forwarding and Commission Merchants ? mnp27-d&w-ly Philadelphia. 11, E 1 FU Roche, Brothers. & Co. ti ll , LTON ST.. NEW YORK; E q VEN uAy. DC131.171:. SiVrtLAND 110P.U. Lirperoot.. JAME!? BLAKELY, Agent, Mire orai'enn at, Canal Basal, Pittranash. Arfortgernotr3 for D OCHE, BROS, & vole Agents for the BLACK lip BALI, LINK , ofl.irerpool awl New Yorktacketv. Luke the liberty of itanouncing to their old rtleal3 and cu. tamers, that their rrangiaoen a for the year IVy tieing complete, they tire prepared to bring out passengers, the above eplendid Line, from Liverpool to New York itild Philadelphia. They role( to their former eoune of doing lidriinevs, and ashore thoie who mired them with their orders, that the Anzac vativfartion will lie rendered ad heretofore. IitIIMITT•NcEs ro .MINGLAND,JRFA.AND, SECYPLAND .AND- WALKS. • Drafts for ,In, payable, on demand, at any Bank in Ireland. The undersigned has made arrangements to bring out passengers tri Pittsburgh. diming the present year. ' het k. •J E. 5 BLANKLY. 11 ARS DM?! dr... CO.'S PLUILIGBII ILKNITITIKR tab -4 Offices AARNDEIN & CO. continue to bring out persons from any part of England, Ireland, Scotland or Wales, opal. the most liberal terms, with their usual punctuality, and attention to the wants of emigrants. W e tin not 01. iosr our pasnengcr.lo be robbed by the swindling scam ps that infest the sea-ports, as we take charge of them the moment they report themselves, and see to their well-be. nth, and despatch them without any detention by the first ships. We say this fe.arlessly, as see ilecy any of our passengers to Acta that they were detained forty-eight hours by Uo in Liverpool. whilst thousands of others were detained months until they could be sent in some old , ft, at a cheap rate, which, too frequently proved their codins. W e intend to perform our contracts honorably, co whirr it may, and not act as was the case last season wit other °races, who either performed not at all, or when i suited their convenience. Drafts drawn, at. Pittsburgh for any sum from LI t El,Otai, payable tiroanr of the Provincial Hanks in Ire land, England, Scotland and Wales. JOSHUA ROBINSON, European and General Aunt, jan2El street, one door below NNootl st. FOREIGN It ENITTANCE. THE Subscribers are prepared to forward money to all parts of - Englund, Ireland. Scotland and Wales, wi th despatch, and at the lowest rates. SA.NRIEL AI'CLURFCEN h CO., 142 Liberty street 2111112 E E== 3115nrammt/Ainipciiiies 1_ ND 11,11rNTY: I. Thei . F2:4212,221121 - OP nritinst.rm.c, - Chdrlec'W Da:ticket, George Bleb:LT(ls, TbaMas-Hart, . .Idortlecui D. LUMP" ?Tobias Wagner, Adolphi E. Borie, Samuel Grant, , David S. Browne ' , Jacob.R: 4 tinith..; ' ' Ifferria isitu. - CHAS. BANCKER, Pr,es'ir CHAS. G.ltastatra, secretary. • Continue'M Make Insurance, perpetual or limited, on every descriptiou of property in town and country, The Company:have reserved a In rge Contingent Fund, 'which, with their Capital and Premiums, stal e ly invested; . afford ample protection to the assured. The Assets of the Company. on January Ist, laid. us e published agreeably to an Act of Assembly, were as fol lows. viz Mortgage e Real Estate .s - .... Temporary_{ ans Stocks Cash; &c. • Since-their ineorporntion, a period of i 9 years, they have paid upwards of One Four Hundred Thou sand Deliers,.losses by lire, thereby atforitig' evidence of the tutv.aniages.of Insurance, ns well as Slm ability and disposttion to meet with promptness, all liabilities. J. GARDINER COFFIN. Agent, Otlice. N. E. corner Wood and 3d sts Fire an.: Marine Insurapce. rrIlE Insurance Company of Ncifth America, of Phila delphia, through its duly authorized Agent, the sub scriber, offers to Make permanent and limited Insurance On property, in this city and its vicinity, and on shipments by the canal and rivers: Arthur G. Coffin, Brooks, Alex. Henry. . Charles Taylor, Santee! W. Jones, Samuel W. Smith, Edward Smith, AHbrose White, John A. Brown, Jacob M. Thomas, John White, John R. Nell. .: Thomas P. Cope, Richard D. Wood, • Wm. Welsh. Henry D. Siterrurd, Sec'y. This is the oldest Insurance Company in the United States, having beenchartered m 1794 . Ito charter is per octant, anti from its high standing, long experience, stn pie means, and avoiding allYisks of an extra hazardous character, it maybe considered as offertie. ' ample securi- . ty to the public. WILLIAM P. JONES.. At Counting Room of Atwood, Jones & Co.,Water and Front its., Pittsburgh mayfly _ AtifilNCY THE FRANKLIN FIRE INSURANCE COMPANY OF PHILADELP. A.—N. E. corner of Third and Wood Oisfets. Piutheirgh.—The assets of the company on the first of January, 1545, as published in conformity with an net of the Pennsylvania Legislature. were Bonds and Mortgages.. Real Ilstate at cost Temporary ' s oans, Stocks and Cash Making a total of $903,6573 Affording certain assurance that all - losses will be promptly met, and giving entire security to all who oh tain policies from this Company. Risks taken at as low rules as are consistent with security. octs WARRICK MARTIN. Agent. -- R. OA sr:AT-10,17 - J. It MILLER GALLAGFIER, LONG & DULLER,. No. 109 Front st., Inticrrn Iriood and Smithfield streets, AT ANUFACTURERS of ite.lls of all sizes. double and .I.IIL. single action Force Pumps., Counter nailing.:Min er./ Vi ttirt rumps, fittings of all kinds for (ins, \Voter, Stettin, &c., Wass Castings sire Machinery and ion metal for some. Particular rist.tition paid to Gan Fixtures. and a well assorted stock of Plain and Orna- Mental Printouts, Outliers, Chandeliers, &e, &e.., coo vonntly on hand. nein 1.111:".5 AILLINTELONQ. ranzEit. A nms•nioNG crtozun. COM 711;311011 Akre/tants, IV No. 92 Market Ktreet. Pittsburgh. Pa, trill ultrad promptly to the tale of every description of \Western Prodner, and other articles eairustrd to OP, r care. Ii EF 7o—l-, alts, & Pitt.hurgh; flouna.„ Graham & Co., New Li abon, O.; Mere hoots generally. . 0..; 0,2 h-by. Bulge port. I.: A. ki hieltardsol) Bro.. J F. I lowu rd. Lout _Ky.; Guth, R Dorwort, st. 1.00, Bo) Struhen cti,e97y - • LAW SCIIIOO — L. - THE Rrlhs ricer will receive at Li office. young (;ea- Steiner de mug to read taw. Ile w ill eitivramend stud direct their - , tudie*. and Ivy cor,lant o . l lperv:*irm,rital etriet teo. kly examilianon. prepare them far arittil•tiitiri to the Bar. ILEA W INt iTUN. The tiuhxcrihars have been in habit of daily proleFsion i! intercourse NA kilt lit tile NVa-blO,lO, toe mast years. anti leek great pletit.lll, in Title-nee' The accuracy of bo, 4.011 ittlurthattket. end llet etritoelll likeintetly for the undertaking •et forth to lu. aclv,^kerncni. • They- earti,oly recoinni, ri to young ( - o-nrimen who Vvi.h to tietittiter it roily(' tent ltt,v.e..,rt• ei Un it.fal pro les...on, To avail thernsclve, tki the Wllltll his propo.ed Law School iv ill a trobl them. . Charlcx tihnler. U..icica'a. A. Bork c. Thor. M'Candieex, C. I)arrn , zii, Robert WoialK. .131(lett Dunlop C 11. Loon.. 'Wirt It .Nl'Clure, Mahan, A %V, LoomiA.: • eta 1 1 :n t, v ii t: C :o:l i r s.:::::: 12 1:::•t i t: t . t: - a ll : t i g . Ts- .4r s. C 7t . • i r 7 i p l s e ft:n , o b .: ... t g - t i tJ , Is the most pupularof.all BOOT and Sti(tPe En ttts reputation try its proptiette..r keel...lig; the yes) . j beg' Roots Otlll 'Aro,. wide)/ nee made , expre.',,,; ys IP order (or tlO*lllfltket. arid Ire Is not aittittftttl only by keeping the best-assorted mock of 1115tYrst nun sliOtts in the Wost6tri country. bill he ... ennobled Witt dieter. 011Itt.11 to roll Iris (iOO.bS tower than nay other honors possibly run, he cares IRO IVIIRI fueilituts they boast Of ' ha V nog foe oliernig great induce:pews to the trundle. It is I ntp0 , ,t1.1 , .. to iel mob nll she ii-di:ottages an.: fat-Mt-ie. in an nsfeeruseitteut. that the Great 11.ato rots corn er t ins Over Others, which enable. its. prtnprietor to sell Hoot.. chid ShO rP. of the vary best nutlities and .ty leis at front 10 : in :15 per rem. lower than, any other store in the city. The way to tent the nuttier is (or all whointend porehs , .. Mc BOOTS nod SIIOE-S. to ca:l nit BATES- GREAT GAM:AIN C7Oll .VEIL examine Iltc stock and prices.nial all will lit satisfied that the Grrof Bargain Corner, Smith- ji,ld and Fifth streets, in the plitei• for the public., suse and all. to get good Boots and Shoes etteno, tines:4ff . deed 11. J. IiATES. Great Weatern Saddle, ' • it.AIiNESS. TRUNIi . AND %WHIP NIAN LFACTORY. 'Via: subscriber takes this method Of infortessor los j_ friends and the public inn general, that he Inn. lire Intreest sleek of the following 'visited triples, nitric own manufacture. in tine city—Saddles. Harness. Trunks SIMI Whips : all of which he will n e urone to be made of the bent tnatorsal. and by the best met-hordes. in A Heghe:ty county Being deter - Mined to sell Int, man uluctures something . lower.lban has been heretofore - sold ill die vity, he would Invite [le r.ort.: in need of line nl.ove named ar ticles. to his IVorehousr. No. gll Liberty .teed, oppo site Seventh. Also, bands, made to order lot' 111,Ittlittotry. 01:t31 c; K•rtl IM __..._ Chlckering's Pianos. JOHN H. MELLOR. (sole .4..—iii Ji, filit i rChkixrin,v's Pianos for lirexttrn Prnnsyl ranie.) No. rq lV nod Street, Pittsburgh, has received, and nriw open for sale. Ilm following elegant assortment or Piario-Fortes, direct trots the manufacturer, And for sale at Mr. Chickering's (Boston) prices, via: One superb 11011412.V0nd, seven octave, carved in the most • Meirunt andstiNtli.yie of Louis •NlV.—new scale. One Rosewood; Carved. seven oelare—new scale. One dn. 6} ortnve—new scale. One do. C. octave, carved moulding—new reale. Two do. 6 do. round cotaers; Two ,to. 6 do. square •• .. ... 'the above are front the maindamory of J. Chickernig. Boston, and of the fittest styles of furniture, and 'Alai his new and approved genie. Also, on hand, and for sale low— Three Rosewood Pianos, ft octaves; from the manufac tory of H. Worcester. New York, formerly of the firm of Stodurt. Worcester A: Dunham. Two Rosewood, ft octave Pianos; from the manufactory of Gale di Co.,N. Y. One Rosewood. 6/ octave; manufactured by Bacon A. Raven, New Vcrrlz. Our. m.nogany 6 octave Piano: made in Baltimore, mid left by the owner for sale, either for cash or in eX flianire inr such goods as will 44 . a country store Price $lOO. innlin ifoliNsToN & sTocgTuN havo ,mat r,:ceivedihe P following new works: History of Congress, Biographical and Political, com prising a history of internal improvements,(:stvers, Har bors, Ac.,) front the formation of the Governirient to the presont time : embracing. also, historical notices of va rious political events of Ocean Steam Navigation; of the Ten and Coffee tax ; lugetilersVilli biographies, PM'. Nonni histories, &e., by Henry CIL litheeler,iiinigrated by Mee! portraits, unit time simile autographs. History of Charles 1, of England; by Jacob Abbott, • I with engravings. The Romance of Yachting; Voyage the First, by Jos. C. Hurt. A new novel ; Mary. Barton : a tale of Manchester life The Moral, Social and ProlCssiatial duties ol' Attorney. and Solicitors; by ehtnnel IVarren,Esq.: F. IL S of the niter temple, Barrister nt Law. • doe.; lron City Cracker and !tread Bakery. J. IMIF,PIJARD IV 01 lie respectfullyl.;l neraliy lha ti i . rtf?Ln: , 11, , I:sie to ntl i s i,, n o ti t tl. e th r e all : ness,the manufacturing of Craekers of every variety.— Having prirchnsed one of W. IL Ncsiu's Cracker nail Pilot Bread machines. he is prepared ro filrulrorileis for crackers or pilot bread at the ettortekt notice and hopes by a strict attention to hue:u - out to share n portion of the public 'norm:tire. The public is respectfitlly invited to call and irk:tonne for themselves. • BAKERY. No. 10 Conatnereial Row, Liberty st. oppo site Smithfield. • • N B. SJperior family Bread,srye nod dyspepsia Bread large mid small rolls, fresh every mornimrunn he had a the store, or my wagon, or at my stand in the market. Cakes and Confectionary on land and made to order. • .L SHEPC ARC.. _npt„V•ty No 10 Commercial Row. Utterly at. --_—__ „--,- hi the best Cough 'Medicine lever Saw." READ the following proofof the superiority of Dr. Wil lard's Oriental Cough 11.11.siure, fronita respectable cit izen; who has tried it: • Ptrrsstraon, 'Dee. 151. -Almon& vs & Rtiockws.v:—After hilioring fur , seve E47 ral weeks under the disadvantages of a harassing cough and most distressing cold, which had, thus far, resisted the ef fects of several of tbe "infallible," I was induced to pur chase a bottle of your g Oriental Cough tore: and give it a fair trial. To my great kurPrise, utter using only one hall of the bottle I found myself entirely writ.. "Ills the best medicine I ever saw." Trite copy. - JOHN HlND'z' Sold by HATS & DROCKWAY,, Druggists, ComMer cial Row. Litierty Street. near Canal. Newiiiillrnery, VolvEts, Joer reeOved from Ni.w York, a choice selce tien of elegant rich Satins, Silks, Wilde: Rtlibons. Preach Flowers,. Plaines, Ate. A handsome: as sorkment of IVinter 13 onnets. Hoods, Capes,' Cardinale, Visetts.k.c. r oil band and made to order in the latest style, of the shortest notice. AIRS. DUFF, ' deefi --ir sI. IWeBl . ~,A FASHIONABLE NI ILLLThIi.V.—AB, S. HARR 4 1 ,7 Fourth street, near IVood, tveulil inform the Ladies e( Pittsburgh and vicinity, lut she will open mi Tuesday. the 24th inst., an extensive assortm e nt of Pal . and Winter Athlinery. er 4 -1- LAA-2 4ticks, just recewed wad Jur nine uy & SINCLAIR $1„047.482 .11 04.724 23 • 25'.001 F 1 ,5 • ,k 1,521. 25 Mi. 204 87 DIRECTORS •Rfrefl 615 93 ••109967 77 •:9:,499 72 No 108 i. C TAIM°B7MII:I"4;!Vtda;',OIN „ Neyee-Asrfin,„and atiSing"fraitil, deran g em etuSor:disenee s .lnthe BiliesyssPlKds• • • live, YaXetilais freipiralerfs and_ Nervous System:es:such coliatipatioit, Unearth- . piles,heittibuimlinstifiappetite,coat / • cd tongue, acidity..of the seem . ash, swimming of tItC: head,. fullness arweight in the. , stomach, dirtiness of • . vision • palpirts ;tied of the • heart; ' : Chbking or suffocating genseting; depression of spirits, sedden flushes of hens - pain in the" side CU - hack, weakness of the limbs, 'Cold! fed, conaiaut int-. aginings 'of evi l,' • fever . nitchstfull'priita in the head, pain fend' 'difteirlik'br breathing when lying upon the - Side,' frightful, drea dussoUrerectatiOnisyellov. - ness of the skin deficiency of perspire- sr lion, &e,&e.sean be effectually, • cured - • by DOCTOR HOOFLAraS_ CELEBRATED GERMAN , 1/74'W.R.S- Their power over the above dise•heini is • not excelled— if equalled—by any other preparation in the Ueited States, as the cures jo this city attests in ma n y easea af ter skilful physiciane had failed: Derangement in the liver end stomach are sources of Insanity—troth disorder or obstruction a morbid action of the sympathetic and 011ier nerves follows, and the func .tions of she brain are • impeired and deiseged; es nerves are the connectirig medium between mind andinatt - er, it follows from the recipro - cal aetion that both "must be more or less implicated and deranged - itirtailtaneously; deriangement there willnlso producediteaseief the SKIN, LUNGS, UTERUS and KIDNEYS. as welt us the brain. The thousands who die with- YELLOW FEVER, ,CIICILERA , or INFLUENZA, is owing to the same eamet;rind the Majority of eases of that most painful disease, CONSUMPTION, otiginatee from the seine. In fact the ;senate!' is the important organ in the system of metier, as upon it you depend for the success Tindall the advtintages to be derived teem the administration of in- Moral medicines. Its functions are of the utmost' Mi -penance to every one in constituting thesourecandfouns !Main of lifeswhich isnuteitiost.,,,Ncseegauposseeeeetaell temeATATe stYinfaithfes; none suehremarkablepower in "modifying every part of the - qstem." The rare euceese in treating disease of the" liver and stomach successfully hes not been awant ofpfitholOgleal• knowledgeot their functions, bee the preparation of a Compound that would act upon the disease mid all the sympathetic afflictions. That point has Steen gained in these Bitters, and they are EN TIRELY.VEGE.TABLE, and will in every ease permanently dtidriy'eestiveneets, and give strength and vigor to the frame, at no time e• bilitating the patiente and they are grateful to the moat -delicate stomach underany circumstances_ • ;s: ALL CAN BE CURED • :I' WHO WILL USE THEM AS DIRECTED, , lie wours TUE ?MOMS Or IIdEDICIXE.) The few months this preparation has been before the publie,hrts; from its infallible efficacy, elicited the eulogy of tlle press through the land., their object being for the benefit of suffering humanity:its success has "surpassed all precedents, and:it is free trout all alcoholic stimulant. syrup, mercury, aloes, quinine, acids, and allifdurious meted tents, and especially adfiptedtothe diseases of the variable climes-13ot the United Steles, and the West In dia Islands. WEEK AND DELICATE CHILDREN. ate made strong by using it—in fact it is a family medi eine, and can he nilministeredwith safety to a child one year old. the delicate Inmate, ors man of ninety. The Philadelphia Democrat says This medicine has an extraordhatry'virtne anti-efficacy, and is In great demand.. We can . speak from experience, that it has produced many wonderful euree." The Daily Sun says:—"We believe it is one of the best medicates of the age—a friend having used it in his own family with great satisfaction in the Jaundice and Liver Complaint." The Spirit of the Times and Keystime says:—"Do our good citizens, whoslre invalids, know the many aston ishing cares that Ilive been performed by Dr. Ifoolland's celeuratea vermeil Bitters? If they do not, we, recom mend them. to the German Medicate Store, '2•78 Rate street: all who arc afflicted with Liver CoMplaint, Jaun dice, Dyepepsia, or Nervous Debility: the Doctor has cared many of our citizens, neer the best physicians had failed. We have used ( hem. and they have proved to be a medicine that every one should know of, and we rennet refrain giving our testimony in their favor, and that which gives them greater claim upon our humble ef fort. they are entirely vegetable. Tile Evening. Bulletin says:—The Celebrated German Bitters are an invaluable remedy for Jaundice, Dyspep sia, and nervous complaints." Neere Gazette eays:—"ll is not often we notice the Various excellent medicines advertised in our columns. bee:ltem we are unwilling to speak except front personal experience, mid a good constitution fortunately makes es e-memfly strangers in Such articles. A word, how . ever of Dr. lloolland'e German Biters. This sva axon Senn excellent artiele fulfilling in every respect what if Claimed for it by the advertiser. .'The Dally Neves says: 'SA 61cm:uses-IVe speak knowingly of Dr, Hoof-, tand'srelebrared German Bitters when we sly it is - a blessing of this age. and in diseases at the biliary, diges tive andnervone syetetne, it has not, we think. at, NUAL' —it iSS IitOrTA.BLI ructeetteren ANO MARS Winton? AL- Colkot,nna to WI invalids we would recommend it as' Woiteythetceonfidestee. What etrong erteitimonr can a medieine laws? At the .DePut Cantle seen the evidences of many of our inns! , respertable citizens of Cures in all the foregoing easels Principe! Depot German Medicine Store, 272 RACE Sztreet. and Inc sale in Lancaster 111, Jobs F. Logan; Har- • riSlitirg i by D. W. Green; nitil -respeetatile dealers-gen erally Iliroussitnal the country. THisT DR EA.rwt; COUGH'—The Lungs IZI ere in danger, the work of the deetmser has been Segue, the,C.ough.of Consumption hush in it a sound of death s , s e , ' Atte sot A ltd, nigh! Your darling child, your idol and earthly joy, pi now perhaps confined to her chamber by a dangerous cold—tier pale cheeks, her thin shrunken fingers, tell the hold discos lots already gained upon her —the sound of her supttlelital cough pigrces your 'tout. YouNG MAN', when jastabOUt tn enter life. dinette° sheds ' heart crushing blight over the.fam prospects of the fit- Sure—Sour hectic rough and feeble limbs tell of your loss of hope, butyou need not despair. There is n balm h e al the wonntted limes, ills AireShma n' A-Ilealn Balsam. Mrs. es, the s wi ll fe of .Wm. l 11. g Attree, sq. was. given up by Dr. Sewell of Waehington. h int' Ro and MeClellnli of Philadelphia. Dr. Roe and Dr. of New pork_ Her friends' all Ihouelit-she must die, She had every appeara nee of being in consumption, and was so pronounced by her physicians—leherman's Balsam was given and ii cured Mrs. (in atiaIIiELANTZ, Of Bull's Ferry, was also shred of eMinulnptioll by . this Balsum when all other remedies ritiled to give relief—she was reduced to a skeleton. Dr. A. , C. - Castle, Dentist, Broadway, has witnessed its effects in several ruses were no other medeente afford ed relief—but the Balsam operated liken tbarm. Dr. C. sled witeesred its wonderful effects in curing Asthma, which it ',ever fails of doing. Spitting Blood s alarming as if May lie, is effectually cared by this bateaux.. 11 heals the ruptured or wounded blood vessels, and makes the lungs sound again. Rev. lIENICY JoN¢s, HO Eighth avenue, was cured of cough and Caturrhal affectioe of 50 years standing. The. first dose gave hint more relief than all, the other medi cine he lied ever taken. Dr. - L. J. 'Beals, 19 Delaney Street, gave it to a sister-in-I:1w who was laborine under. Consumption and to another sorely afflicted with the Asthrmt. In both ruses its effects were immediate, soon restoring them to comfortable health- Mr, Inetterte Wers-s, 05 Chrietie-stS, suffered from Asthma 42 years. Shermatee Balsam relieved het at ogee, and she is comparatively well, being enabled to subdue every :lunch by' a timely use of tins medicine. This indeed is the great remedy for Cou g hs. Colds, S'pit- • ring Blood. hirer Complaint's and all theeffections of the • throat, end eve:, Asthma and Consumption. Price 25 rents and SI per bottle, Principal Office the Nassau street. New York. Likewise Dr. SlierMaida celebrated Cough, Worm and Camphor Lozenges. Premium Tooth Paste and Poor Man's Plaster" Sold wholesale and retail by WE. JACKSON, at his Boot and Shoe Store rind Valeta elielicine Warehouse Liberty Street Pittsburgh, head of Wood street. mai by the. following duly appointed Agents for Allegheny county : A. NI. Marshall. Allegheny city; Jenruhan Gluiest, Mancliester; J. R. 11. Jaectuee, Birmingham; A. S. Getty, Wylie street; J. G. Mustin. tor. Webster st. and Eine Daniel Negley, East Liberty; H. Is Mitchell, Wilkins burgh; This Aiken, Sharrifilmrgh; Saml. Springer, Olin-. ton: James IM'Kee. Stewartstown; John Black. Turtle Creek; C. F. Diehl, Elizabeth; Rowland & Son, APKees port; MeEldowney, Bakerstowu; Riley 111 , 1auglatin, Plumb Township; Wtn. J. Smith, Temperance . ..elle; Jas, Fulton, Tarentum• G.ll. Starr, Sowiekly. marfl-ly MttttE TESTIMONY!—Dr. W. LANDS, of Fayette: stile, N. I'., nays: "I run perstiaded, and have been for some time, that your Domestic Vegetable Pills are of great use to ell Moe, who may have occasion to use them, and have administered teem to my patients." Fever, and Ague, Dyspepsia and Bilious Fever, are im mediately- cared by the see of Dr. Ralph's Pills. Price, 25 cents a box. Sold wholesale and retail by st. L. CUTHBERT, Sthfild stret. near Th Alen. by Win. Cole _ Alleg mi heny e city; J. G. Smith,ird. I3ir minghtitn; and John M'Craiiken. Firth Wesel. fehl7 Jaynes , Family Me dictate. "FIR. S. S. COOK. Pig,r, Ohio, writes, March, ISM: have used your emu/lige, Carniittative Ralsath, anti Expreverniu, in my practice, for the 'lest three years, salt hese be e n exceedingly well pleased with them, amid utter, us yet, to my 1 - et:envenom failed of realizing my fullest expectation in their curative properties. Your other inedicittem I cannot speak of from experience; but, Judging from those I have used, I doubt not but that they clams and are entitled to all the eolifidellee 'reposed in them, by those who have used tnem. I was formerly very partial to essse Vermifuge,. until I Lecameacquatit red with yours, which has my decided preferene to any other now in use. Reasectfully, yours, &C., S. S. COOK, NI D.. fr: - Far sale in Pittsburgh at the Pekin Tea Store, PS Fourth st. fehls Al EA SINESTOCK'S COUGH scRI I), ' , oration has proved itself to be of very great efliett ey in the cure of obstinate Coughs, Colds, Asthma, Spit ting' of Blood, Whooping Coug, anti other Pneumonic Affeetione; and the proprietors feel warranted in recant recoiling it an a safe and useful medicine, and are pre pared to Acne_ certificates of iedisputable authority, it testimony of its value. • It is pleasant to the tamp, and is offered ate° low a price its to place it within the reach of every person. There are. perhaps, but few Cough preparations that will pro 'din, such decided effects in such a short time.. Pre pared turd sold by B. A. FA HNESTOCIC .& CO, Corner of First and Wood; also, confer . ofSixth and World streets. dse.l3 ._.... ~ . BALPA'S CELEBRATED VEGETABLE PILLS are far D R. 'sale, wholesale and retail, at the REAL FAnATE OFFICE, o. O. Smithfield ab Algo, by Wm. Cole, Allegheny drys J. G. Smith, 13ir tninglin rm John. McCracken, Penn street, Fifth Ward. feb =Etni -- w. C coNNELLY: }MOWN'S C'dn.YER OP SEITIWIELD AND THIRD•STS., Pittsburgh, P. DROWN ..v,CONNELLAI, PROPRIETOR&Ni I3.—Good Stabling attached to the - house. I ppI,LS-100 bbls. fine eating` and cooking Apptes, Tee,'d persteamer " Consul," and for sale by 'deetr7 KING & 11100RHEAD • •-.4. • rt t r' hnb -e -growth,: beattlYoutdaistoration of life Hair. - This Cream. - when *olieekttoWricvvill-supereede iiithirarti cles of the kind now in use. II hire . Wei hatr is dead harsh, thi, unhealthy, air.. turiduggrey, a few applica tions will'make the-India-oft antrdark;'andgiire it. a beau-., tiro!, 'liVely 'apPeennice; Will also nialie it inabitain" its.lyfelittestr and' heithliteoler; twice he liingtta all the: preparations that are generally, used. Where the bald thin,' or hits fallen ofit' May. be restored bytishig th'f Cream. Every lady an ' dgentlentan F 40,41.11 the habit . of using oils on their heir, should at OneepurchasealiottleCif the. Chinese Hair . Creami:ais it is tiotompesetithat it l / 4 111 , not injure the hair like the 'other prepamtions, but Will, beatitifylii and - - give lierfect'satisfaction in every - in_ stance. - For testimony Mini .very,superior qualities, see the col lowing _letter from the '.Rei..lllr.. CaldWell Hendeishintle.: Streteh,NighAlle, general, agentsfor the;'. Letter 'o,omArv. ptete.Frerbltfriiti hlrisslrs.Ffirkintlignarr. tr. =arca: 'Gaßritreati-4 take p.eicsure in adding my testimony in - favor addite excellent prepare:lon called Dr. PoiislOst7thiezie Cream; for, abof - t- two %years agora:Their was very drY, bristle; and disposed to come out; -but aving procured-a bottle of the,' Cream, and used it according to ilie pre sc nation, i t noW elastic, soft, and, firm' to. the head. 2 Minty baliamsand oils were , applied, each leaving-my hair itr a worse state than before. This.Cream r however has met - My expec tations. As an article for-the toilet,, my.wife-gtves it preference over all others, being delmately_perfurned and not disz posed:to rancidity. The ladies, especially, will find the Chinese Cream to be a desideratum theirptettarationis' for the toilet. Respectfully, &e, • ; • Pulaski, January 7,1847. _ • wholesale_and, in,Pittsburgh, by John M. Townsend, 45 Marketet., and.-Joel Mohler, corner of 'Wood and Fifilsta. • r • - • - - LA DIES are cautioned agamta using Common Prepa red.. Chalk Theyare not aWatehoWfrightfull3r inju rious it is to the skin'. how corirae, how rough; flOWBllllO*, yellow, and unhealthy the skin appears - after using pre, .pared chalk -Resides It isinjunotis,c - oritaining a large quantity of ..We have prepared a:beautiful vege table ankle, whielt"we .6111:Jones' Spanish Lilly White. -It is perfectly' innoCent, being Parifted