Texas A&M COLLEGE STATION, Texas Scientists at Texas A&M Uni versity have successfully cloned what is first calf cloned from an adult bull, which is . also the oldest animal ever cloned a 21-year-old Brahman. Their research could have enormous im plications in the beef cattle indus try and in the future applications of cloning technology. Researchers Jonathan Hill and Mark Westhusin accomplished the cloning of the bull, fittingly named “Chance,” in a year-long Chance’s offspring, “Sec ond Chance,” was bom three weeks ago and displays identical markings'as his father and has identical DNA, the researchers say. ‘The owner* of Chance, who arc from LaGrangc, Texas, want ed to have their prized bull cloned because of his unusually gentle nature, and they considered the cloning effort a good opportunity to see if an identical copy of Chance might also have such an easy going disposition.” Hill said. “Chance was great around people, and he wa* in several TV commer cials, performed hi the Houston Rodeo and was even on The Late Show with David Letterman,” Hill added. "They want to see if Sec ond Chance lives up to his heri tage.” Hill said the bull was unable to reproduce naturally because of the removal of both diseased testicles two years ago. Therefore, he said, cloning Chance was the only op tion for preserving his genetics. Scientists Clone First-Ever “Second Chance is obviously an intact male and should be able to sire offspring when he reaches puberty,” Hill confirmed. Chance died a few months ago at age 21, shortly before his DNA was used to produce Second Chance. Hill said there is considerable interest in keeping track of Second Chance throughout his lifetime because of the age of the cells used to clone him. Last spring, scientists revealed that the DNA of Dolly, the first cloned sheep, had some character istics of the older cells that were used to generate her. “The chromosomes, which package the animal’s DNA, have some special DNA at their tipi called telomeres,” Hill explained. "These small pieces of DNA help to protect chromosomes from damage. Very young animals have long telomeres, but as the animal ages, the telomeres ate worn away. We should know in a month or so if the telomeres of Second Chance are like those of the 21-year-old bull used as the sour ce of the.cclls for the cloning pro cess. or ff they are more like those of a normal newborn calf.” Hill said it took 189 attempts that is, transferring 189 cells into 189 different eggs before a pregnancy ended in the delivery of Second Chance. Because Second Chance came from the oldest animal cloned to date, he has received intensive monitoring and treatment since birth by a team of veterinarians and intensive care technicians at the Texas A&M Large Animal Hospital. Like many previously cloned calves, at birth he dis played some symptoms that re sembled those seen in premature human babies. However, Second Chance is now in good health. Hill said. The successful cloning effort could dramatically impact the multi-billion dollar beef cattle in dustry in Texas and throughout the world. “This could lead to new oppor tunities in cattle breeding, and for that matter, other animals," Hill believes. Hill is a veterinarian trained in Australia and at Texas A&M who used the cloning work as part of his doctor of philosophy studies in physiology with Wes thus in. He is also a member of another research team led by Westhusin that is in volved in the Missyplicity Project, the first-ever attempt to clone a dog. The Miisyplicity Project is a 2-year effort to produce the first cloned dog. The anonymous spon sortof die project have invested $2.3 million to produce a clone of their pet dog. Missy, a mixed breed border collie. A team of about 20 researchers is working on the Missyplicity Project, and some of the knowledge gained by Second Chance is helping to ad vance that research. 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