D22—Lancaster Farming, Saturday, July 16,1983
• BELTSVJLLE, Md. -
Genetically engineered proteins,
required as a first step in devising
a potential vaccine against a
serious disease of poultry, will be
produced by three companies
under an agreement with the U.S.
Department of Agriculture.
Harry D. Oanforth,
microbiologist with USDA’s
Agricultural Research Service,
said today that the joint venture’s
goal is to develop a broad-range
vaccine against coccidiosis. This
parasitic intestinal disease an
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Agreement reached on coccidiosis research
nually costs the U.S. poultry in
dustry more than $l5O million in
direct Josses and about $lOO million
for anticoccidial drugs, he added.
Joining USDA in the agreement
are Hoffman-La Roche, Inc.,
Nutley, N.J.; Genex Corp.,
Rockville, MD.; and Vineland
Laboratories, an affiliate of Im
munoGenetics, Inc., Vineland,
N.J.
According to the agreement,
proteins called antigens will
produced by use of monoclonal
antibodies furnished by USDA’s
research agency, Danforth said.
Agency researchers are
producing these antibodies via the
hybndoma technique wherein
spleen cells from mice inoculated
with the coccidial parasite are
fused with mouse cancer cells
grown in cell cultures.
Fused cells resulting from this
biotechnology not only possess the
immortality of cancer cells but
also manufacture identical an
tibodies that react with specific
forms' of chicken coccidiosis,
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Danforthsaid.
Oanforth and his colleagues at
the Poultry Parasitic Diseases
Laboratory here have produced
monoclonal antibodies against
several species of coccidiosis.
Their work, reported last year at a
meeting of the Poultry Science
Association, was considered the
first step m formulating a vaccine
against the disease.
The agreements to produce the
antibodies were executed here on
June 29 by William H. Tallent,
administrator for the Northeast
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Region of ARB; L. Patrick Gage
for Hoffman-La Roche; Joseph G.
Perpieh for Genex Corporation;
and John F. Bradley for Vineland
Laboratories.
All three companies in the
project had responded to a
government request for proposals
published in Commerce Business
Daily, Danforth said. Each
agreement, or memorandum of
understanding, defines procedures
of USDA-mdustry cooperation, but
does not transfer funds between
any of the parties.
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