Chemical Feed Additive to Fight Marek’s Disease Reported
Discovery of a chemical
compound that shows promise as
a feed additive to reduce mor
tality and visceral lesions caused
by Marek’s disease in chickens
has been reported by scientists
from Merck & Co., Inc.
They said that the compound,
called AUS, will have to undergo
extensive field testing for further
evaluation of its safety and ef
ficacy before any marketing
decisions can be made. Some
field trials are already in
progress.
In artificial infections with
several strains of the herpes-type
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I Mile North of Terre Hill on Eoute 897
East Earl, R.D.I, Pa. Phone 215 445-6272
John J. Hess, 11, Inc.
Ph; 442-4632
Paradise
West Willow
Formers Assn., Inc.
virus that causes Marek’s
disease, AUS was effective at
dose levels as low as 0.0002 per
cent in the diet. The action of AUS
in these tests proved to be
primarily prophylactic; it
prevented the symptoms of
Marek’s disease from developing
in the chicken.
Dr. T. Y. Shen, Director of
Chemical Research-
Inflammation and Viral Disease
of the Merck Sharp & Dohme
Research Laboratories, traced
the long history of discovery and
described testing results in a
paper presented at the annual
Purina Dairy Conditioner Special can prepare
cows for good production at low cost
Ph: 464-3431
West Willow
“Fetter
Power Pays”
LD LEADERS IN
N
If you’re not among the many good local
dairymen who have started mixing
Purina Dairy Conditioner Special with
your own grain to build a research
proved dry cow ration, it can pay you to
check into this low-cost way of feeding
dry cows.
Purina Dairy Conditioner is a 16 percent
protein ration, fortified with extra Vita
mins A and D plus phosphorus to help
guard against milk fever.
To help you save on dry cow feeding,
Purina Research recommends varying
feeding levels, depending on cow condi
tion and the quality of your roughages.
For example, if a cow is in good condi
tion and your roughages are of excellent
quality, you would feed less Purina dry
cow ration than if the cow were in only
fair condition and if the roughages were
of only fair quality.
•Reg. Trademark—Ralston Purina Co.
John B. Kurtz
Ph: 354-9251
R. D. 3, Ephrata
Ira B. Landis
Ph: 394-7912
1912 Creek Hill Rd. f Lane
meeting of the American
Chemical Society in Washington,
D. C. on September 15.
A major contributor to the
commercial development of a
Marek’s disease vaccine, Merck
has been marketing its ‘Dep
tavac-HVT’ vaccine under
license from the U. S. Depart
ment of Agriculture since March
1 this year.
Concurrently, however, the
company has maintained a
research program started in 1965
to find a chemical means of
controlling the poultry disease
that causes losses estimated as
high as $l5O million a year.
In the course of this program,
Merck scientists screened many
known anti-virus and anti-tumor
compounds and determined that
none had protective action at non
toxic levels.
Other approaches turned out to
be more productive. Tests with
several hundred sulfanilamide
derivatives showed that a
number of them had some degree
of activity against Marek’s
disease, but that this activity was
in no way associated with their
Statement of Ownership, Management, Circulation
Required by the Act of Congress of October 23, 1962
(Section 4369, Title 39, United States Code)
Of the Lancaster Farming published weekly at Lititz, Penna
for October 1, 1971.
The name and address of the publisher is:
Campbell, Lititz, Pa. Editor, Zane Wilson, Lititz, Pa.
The owner is:
Robert G. Campbell, Lititz, Pa.
The known bondholders, mortgagees, and other security
holders owning or holding 1 percent or more of total amount
of bonds, mortgages, or other securities are: None
Average No. Copies Single Issue
Each Issue During Nearest To
Preceding 12 Months filing date
5852 6100
A. Total No. Copies Printed
B. Paid Circulation
1. Sales through agents
2. Mail Subscriptions
C. Total Paid Circulation
D. Free Distribution
. 1. Sample, complimentary, and
other free copies
2. Copies distributed to news
agents, but not sold
E. Total Distribution
F. Office Use, leftover, unaccounted,
spoiled after printing
G. Total
I Certify that the statements made by me above are correct
and complete. Robert G. Campbell
Publisher
anti-bacterial or anti-folic acid
properties.
The research team next turned
to dapsone, a sulfone compound
used in treating human leprosy
and) bovine coccidiosis and
strejftococcal mastitis. A large
number of dapsone analogues
were synthesized and assayed to
determine which showed
maximum activity against
New Federal
A new federal occupational
safety law concerns farmers,
farm workers, and farm owners.
The Occupational Safety and
Health Act of 1970, went into
effect July 1, 1971.
Described as one of the most
important pieces of legislation of
its type ever passed, it provides
that both employers and em
ployees have separate but related
responsibilities and rights with
respect to achieving safe and
healthful working conditions.
Attention should be directed to
Using Purina Check-R-Mix* formulas we
can build you a low-cost dry cow ration,
combining Purina Dairy Conditioner
with your grain. Or, if you’re feeding
low-protein roughages, it may pay you
to feed Dairy Conditioner “straight”
just as it comes from the bag.
More and more successful area dairymen
are proving that good dry cow feeding
pays off in extra cow condition and
extra milk production in the next lacta
tion. For example, 100 to 200 pounds of
additional body weight at freshening can
pay off in 1,000 to 2,000 pounds of extra
milk during the lactation.
Drop in soon and get your free copy of
the Purina Dry Cow Program folder
We’ll be glad to point out how Purina
Dairy Conditioner Special can help pre
pare your dry cows for good production
at low cost.
James High & Sons
Ph: 354-0301
Gordonville
Wenger's Feed Mill
Inc.
Ph: 367-1195
Rheems
Lancaster Farming, Saturday, October 9,1971
Safety Law
Robert G
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6022
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000
5763
5763
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6061
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5805
39
6100
47
5852
Marek’s disease with minimum
toxicity. It was from this phase of
the program that AUS was
developed.
Merck indicated that field
trials are being conducted chiefly
under broiler growing conditions.
Chicks will be put on feed con
taining AUS from the outset and
will remain on such feed
throughout the growing period.
Is Described
a unique feature of the law
requiring action by employers of
all types, including farmers with
hired help.
This is a provision for recor
dkeeping. It requires that em
ployers maintain and make
available to the U.S. Department
of Labor accurate records of
work-related deaths, injuries and
illnesses, except those requiring
only minor first aid treatment.
Employers must also keep
records of employe exposure to
potentially toxic materials or
harmful physical agents, and
their employes must be notified
of exposure to such toxic
materials or harmful agents.
This latter provision is
especially applicable to farmers
applying dangerous pesticides in
cropping operations
A booklet titled Record-
Keeping Requirements Under the
Williams-Steiger Occupational
Safety Act of 1970 is available
from regional offices of the U.S.
Department of Labor. The ad
dress for the Middle Atlantic
regional office serving Penn
sylvania and adjacent states is as
follows:
Joseph S. Perzella, Regional
Director, U.S. Bureau of Labor
Standards, Penn Square
Building-Room 410, Juniper and
Filbert Streets, Philadelphia, Pa.
19107 (Phone: (215) 597-4103).
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